Delmic licenses Cryo Workflow Tools developed together with Max Planck Scientists

Delmic Cryo B.V. and Max Planck Innovation GmbH have signed a licensing agreement for production and distribution of Cryo Workflow Tools invented and developed by the group of Prof. Dr. Stefan Raunser, Director at the Max Planck Institute for Molecular Physiology in Dortmund (MPI). The Cryo Workflow Tools are aimed at reducing ice contamination, a major obstacle in the cryo electron tomography (cryo-ET) workflow. The new product with the name “Delmic CERES Ice Defence System” will be launched in March 2021.

Quelle: IDW Informationsdienst Wissenschaft

Delmic lizenziert gemeinsam mit Max-Planck Wissenschaftlern entwickelte Kryo-Workflow Tools

Delmic Cryo B.V. und Max-Planck-Innovation haben einen Lizenzvertrag für die Produktion und den Vertrieb von Kryo-Workflow Tools vereinbart, die in der Forschungsgruppe von Prof. Dr. Stefan Raunser, Direktor am Max-Planck-Institut für Molekulare Physiologie in Dortmund (MPI), erfunden und entwickelt wurden. Die Kryo-Workflow Tools reduzieren Eiskontaminationen, die ein häufiges Problem im Workflow der Kryo-Elektronentomographie darstellen. Das neue Produkt mit dem Namen „Delmic CERES Ice Defense System“ wird im März 2021 auf den Markt gebracht.

Quelle: IDW Informationsdienst Wissenschaft

Production of sustainable food in aquacultures – without microplastics and pollutants

Hof, 02.03.2021 – Sustainable food production in aquacultures entirely without microplastics – that is the long-term goal of a new research project at Hof University of Applied Sciences that will run for two years. The scientists led by project manager Prof. Dr. Manuela Wimmer have now received funding of EUR 220,000 for „BioBioCarrier“ from the German Federal Ministry of Economic Affairs and as part of the Central Innovation Program for SMEs (ZIM).

Quelle: IDW Informationsdienst Wissenschaft

A global assessment of cancer genomic alterations in epigenetic mechanisms

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira

Abstract

Background

The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.

Results

Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.

Conclusions

This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.

Continue reading „A global assessment of cancer genomic alterations in epigenetic mechanisms“