The EU has banned animal testing for cosmetics and non-animal alternative methods are preferable for the risk assessment of new chemical substances. At the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, a three-dimensional skin model has now been set up for the first time that directly displays the skin’s reaction to substances: The reporter skin. Thanks to the built-in reporter, the cellular response can be measured precisely and quickly – using a living model. This means that not only cosmetics can be tested effectively, but also allergens and the inflammation-causing or toxic effects of biocides, pesticides and chemicals.