Poisoning with paracetamol (acetaminophen – APAP) is a common cause of liver failure. However, not all the correlations that lead to liver damage from APAP are yet known. Especially the role of bile acids is unclear. The Leibniz Research Centre for Working Environments and Human Factors in Dortmund (IfADo) has therefore investigated why the concentration of bile acids increases in the liver after APAP poisoning. The researchers have published the latest findings in the Journal of Hepatology: The bile acids are repeatedly fed into the liver through a circuit instead of flowing directly out of the liver. Interrupting this circulation massively reduces liver damage.