Itchy eyes, sneezing, and sinus pressure: Allergic Rhinitis (AR), caused by specific pollen antigens, is one of the most common chronic allergic respiratory diseases worldwide. In 2019, 38.8 percent of the entire Japanese population was affected by AR caused by Japanese cedar pollen. Inadequately controlled symptoms not only limit the quality of life of those affected but also lead to major economic losses. The results of a recently published WifOR study show that the humanized monoclonal anti-immunoglobulin E (IgE) antibody Omalizumab can significantly lower this burden.