Scientists from the MPI for Medical Research and colleagues have engineered synthetic exosomes that regulate cellular signaling during wound closure. The synthetic structures resemble naturally occurring extracellular vesicles (EV) that play a fundamental role in communication between cells. The scientist uncovered key mechanisms to regulate and aid wound healing and the formation of new blood vessels. Inspired by the function of their natural blue prints, the scientists successfully demonstrate for the first time that fully-synthetic exosomes with therapeutic functionality can be constructed. The results were recently published in Science Advances.