Serious courses of COVID-19 disease are concurrent with an immune system that went out of control, whereby major amounts of immunological messengers are released. Contrary to previous assumptions, immune cells from the innate immune response obviously do not play a relevant role in these processes. This is the result obtained by a research team at the Paul-Ehrlich-Institut, headed by Prof Zoe Waibler and Dr Martina Anzaghe, as well as by Prof Georg Kochs’ group at the University Hospital at Freiburg. The subject of the study was the impact of a SARS-CoV-2 infection on important players of the immune system. Frontiers in Immunology reports on the results in its online edition of 26.05.2021.