Bayreuth study on the activation of the enzyme sirtuin 6: Toward the development of drugs for aging-related diseases

In the search for ways to effectively combat age-related human disease, the enzyme sirtuin 6 (Sirt6) has recently become a focus of biochemical research. A targeted activation of Sirt6 could prevent or mitigate such diseases, for example some types of cancer. In a paper for the journal „Nature Chemical Biology“, biochemists from the University of Bayreuth have now shown how the small molecule MDL-801 binds to the enzyme Sirt6 and influences its activity. These findings stand to aid the development of new drugs.

Quelle: IDW Informationsdienst Wissenschaft