Exactly 20 years after the successful completion of the „Human Genome Project“, an international group of researchers, the Human Genome Structural Variation Consortium (HGSVC), has now sequenced 64 human genomes at high resolution. This reference data includes individuals from around the world, better capturing the genetic diversity of the human species. Among other applications, the work enables population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation, as the 65 authors report in the current issue of the scientific journal Science.