New approach explains how protein complexes regulate cancer genes

While NUP98-fusion proteins have been shown to cause leukaemia, the molecular mechanisms have so far been unknown. In a recently published study that was led by Vetmeduni Vienna, researchers have now been able to decipher an important part of these mechanisms. According to the study, a possible driver for the activation of leukaemia genes is the very dynamic complex formation of NUP89 fusion proteins with other proteins in a process known as biomolecular condensation. This finding could contribute to the development of more effective and targeted cancer therapies that would be of particular benefit to children suffering from acute myeloid leukaemia (AML).

Quelle: IDW Informationsdienst Wissenschaft