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For protein molecules that contribute to metabolism, it is often crucial how they interact with other components of their metabolic pathway. Scientists at the Max Planck Institute for Developmental Biology in Tübingen have now investigated a natural enzyme complex that comprises ten enzymes with five different activities. The result: the molecular architecture is surprisingly compact, yet offers individual enzymes maximum free moving space, which opens up novel perspectives for drug discovery. The scientists are now publishing their results in nature chemical biology.