Uncovering novel relationships between solute carrier transporters and cytotoxic drugs in human cells

CeMM Researchers have studied how Solute Carriers (SLCs) influence the activity and potency of cytotoxic drugs, such as those used in the treatment of leukemia and other cancers. Their study, published in the journal Nature Chemical Biology, uncovers the dependency of most drugs studied on the function of at least one SLC. In some cases, the drug required the transporter to enter into the cell, in other cases, it provided small molecules (metabolites), which are crucial to the drug’s activity or the cell response to it. These findings shed new light onto the biological roles of transporters and open the path to the development of future precision therapies.

Quelle: IDW Informationsdienst Wissenschaft