Fatal overproduction of antibodies: Mutations in plasma cells play a key role in light chain amyloidosis

Bone marrow plasma cells produce antibodies. These comprise two long and two short protein chains. The pathological proliferation of plasma cells can lead to an overproduction of the short chains. These associate to fibrils and deposit in organs. The result is fatal organ failure. A research team from the Technical University of Munich (TUM) and Heidelberg University has now identified the mutation behind the disease in a patient.

Quelle: IDW Informationsdienst Wissenschaft