Pioneering cell therapies for non-responders to current immunotherapies

New research signposts a new, less invasive approach to identify killer T lymphocytes in patients with gastrointestinal tumors with low mutational burden who are refractory to approved immune-based treatments.

Quelle: Sciencedaily

New marker for tumor aggression in neurofibromatosis type 1

A new study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1. According to the researchers, the clues could advance the search for more customized and relevant treatments that spare patients exposure to treatments unlikely to work.

Quelle: Sciencedaily

Protein misfolding as a risk marker for Alzheimer’s disease

In symptom-free individuals, the detection of misfolded amyloid-beta protein in the blood indicated a considerably higher risk of Alzheimer’s disease — up to 14 years before a clinical diagnosis was made. Amyloid-beta folding proved to be superior to other risk markers evaluated.

Quelle: Sciencedaily

Oxygen in hyperbaric chamber provides relief after radiotherapy

Hyperbaric oxygen therapy (HBOT) can relieve self-reported symptoms and side-effects of radiotherapy against cancer in the pelvic region, a study shows. After 30-40 sessions in a hyperbaric chamber, many patients experienced reductions in bleeding, urinary incontinence, and pain alike.

Quelle: Sciencedaily

Progress in global cancer fight is not only possible, but achievable

The Cancer Atlas, 3rd edition, a comprehensive global overview of cancer around the globe, concludes that progress in the fight against cancer is not only possible, but achievable.

Quelle: Sciencedaily

Machine learning tool refines personalized immunotherapy

Scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.

Quelle: Sciencedaily

‚Back in time‘: Researchers unravel early makings of an exhausted T cell

Researchers explore the path to T-cell exhaustion and what triggers it is.

Quelle: Sciencedaily

DNA fracturing rewires gene control in cancer

A multi-institutional team has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

Quelle: Sciencedaily

New method for quicker and simpler production of lipidated proteins

The new method is leading to a better understanding of natural protein modifications and improved protein therapeutics.

Quelle: Sciencedaily

Scientists help immune system find hidden cancer cells

Cancer cells are masters at avoiding detection, but a new system can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss.

Quelle: Sciencedaily

Shipment tracking for ‚fat parcels‘ in the body

Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks — including for the envelopes of living cells. Numerous diseases are related to disorders in the fat metabolism, such as obesity or cancer. Researchers are now demonstrating how the fat metabolism can be monitored down to the individual liver cell of a mouse with the greatest sensitivity.

Quelle: Sciencedaily

Overweight before age 40 increases the cancer risk

The risk of cancer increases considerably if you gain weight before the age of 40.

Quelle: Sciencedaily

Algorithm personalizes which cancer mutations are best targets for immunotherapy

As tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model hand-picks those needles so they can be leveraged in more effective, customized cancer vaccines.

Quelle: Sciencedaily

When studying immune cells, environment matters

For years, scientists have used cells grown in petri dishes to study the metabolic processes that fuel the immune system. But a new report suggests looking outside the dish and into living organisms gives a drastically different view of the way immune cells process and use energy.

Quelle: Sciencedaily

Modelling ion beam therapy

A group of physicists have used Monte Carlo modelling to produce a consistent theoretical interpretation of accurate experimental measurements of ion beams in liquid water, which is the most relevant substance for simulating interactions with human tissue.

Quelle: Sciencedaily

New mechanism fueling brain metastasis

Scientists described a novel mechanism through which astrocytes, the most abundant supporting cells in the brain, also promote cancer cell growth and metastasis in the brain.

Quelle: Sciencedaily

Virtual review of cancer clinical trial treatment options quicker than conventional method

Using virtual, cloud-based, interconnected computing techniques applied to 51,000 variables, researchers reduced the time needed to assess a cancer patient’s tumor profile and suitability for clinical trials from 14 to 4 days. This method also increased two-fold, over a four-year period, the number of cases that could be assessed compared to conventional methods.

Quelle: Sciencedaily

New cancer-driving mutation in ‚dark matter‘ of the cancer genome

A research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the ‚dark matter‘ of human cancer DNA.

Quelle: Sciencedaily

‚Wild idea‘ opens possible new frontier for preventing ovarian cancer

A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

Quelle: Sciencedaily

Blood test could help to accelerate brain cancer diagnosis

A blood test which could help to accelerate the diagnosis of brain cancer has been developed in new research.

Quelle: Sciencedaily

How common genetic mutation drives cancer

A new, multicenter study has determined how a single mutation in splicing factor 3b subunit 1 (SF3B1), the most frequently mutated splicing factor gene, drives the formation of many cancers.

Quelle: Sciencedaily

Potential liver cancer treatment by targeting cancer stem-like cells

Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.

Quelle: Sciencedaily

Insights on treatment and prognosis of male breast cancer

A recent analysis reveals that treatment of male breast cancer has evolved over the years. In addition, certain patient-, tumor-, and treatment-related factors are linked with better survival.

Quelle: Sciencedaily

Innovative pancreatic cancer treatment may rev up immune system

A research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an ‚immune memory‘ in the same way that a vaccine keeps the flu away. The result is that the combination treatment also destroyed pancreatic cells that had spread to the liver, a common site for metastatic disease.

Quelle: Sciencedaily

Skin cancer prevention program may have reduced melanoma in Australians

A skin cancer prevention program called SunSmart may have contributed to a recent reduction in melanoma among younger residents of Melbourne, according to a new study. According to the authors, the findings may have substantial implications for the future delivery of skin cancer prevention programs.

Quelle: Sciencedaily