More evidence that cellular ‚death by iron‘ could be promising avenue of cancer treatment

Genetic mutations that give cancers a metabolic boost may also leave them vulnerable to drugs that promote a particular form of cell death, researchers have found.

Quelle: Sciencedaily

Cancer cells ‚remove blindfold‘ to spread

Cells are effectively ‚blindfolded‘ as they lose sensitivity to their surroundings early in cancer progression, but scientists used a new method to find some cancer cells are able to switch this sense back on in order to move and spread. In future, these cells could potentially be targeted by treatments before cancer spreads to give patients a better chance of recovery.

Quelle: Sciencedaily

Telomere shortening protects against cancer

Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body’s cancer prevention system.

Quelle: Sciencedaily

AI predicts which drug combinations kill cancer cells

A machine learning model can help us treat cancer more effectively.

Quelle: Sciencedaily

Combination therapy might improve outcomes in treatment-resistant liver cancer

A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified. The dual therapy — which combines the multikinase inhibitor drug regorafenib to ‚reprogram‘ the tumor immune microenvironment, and programmed cell death 1 antibodies to stimulate anti-tumor immunity — improved survival in mouse models of HCC beyond what each therapy could have achieved alone.

Quelle: Sciencedaily

Researchers unlock the door to tumor microenvironment for CAR T cells

Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice.

Quelle: Sciencedaily

Connection between gut bacteria and vitamin D levels

Researchers discovered that the makeup of a person’s gut microbiome is linked to their levels of active vitamin D, and revealed a new understanding of vitamin D and how it’s typically measured.

Quelle: Sciencedaily

Simulations open a new way to reverse cell aging

Research findings provide insight into the complex mechanism of cellular senescence and present a potential therapeutic strategy for reducing age-related diseases associated with the accumulation of senescent cells.

Quelle: Sciencedaily

Researchers uncover the unique way stem cells protect their chromosome ends

Telomeres are specialized structures at the end of chromosomes which protect our DNA and ensure healthy division of cells. According to a new study, the mechanisms of telomere protection are surprisingly unique in stem cells.

Quelle: Sciencedaily

Space travel can adversely impact energy production in a cell

Studies of both mice and humans who have traveled into space reveal that critical parts of a cell’s energy production machinery, the mitochondria, can be made dysfunctional due to changes in gravity, radiation exposure and other factors. These findings are part of an extensive research effort across many scientific disciplines to look at the health effects of travel into space.

Quelle: Sciencedaily

Channeling the immune system for head and neck cancer

Researchers have discovered new clues into why some people with head and neck cancer respond to immunotherapy, while others don’t.

Quelle: Sciencedaily

Understanding the utility of plasmas for medical applications

Plasma medicine is an emerging field, as plasmas show promise for use in a wide range of therapies from wound healing to cancer treatment, and plasma jets are the main plasma sources typically used in plasma-surface applications. To better understand how plasma jets modify the surfaces of biological tissue, researchers conducted computer simulations of the interaction between an atmospheric pressure plasma jet with a surface that has properties similar to blood serum.

Quelle: Sciencedaily

Therapeutic PD-1 cancer vaccine shown to be safe and effective in animal study

A study has described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor.

Quelle: Sciencedaily

Boosting stem cell activity can enhance immunotherapy benefits

Immune-system T cells have been reprogrammed into regenerative stem cell-like memory (TSCM) cells that are long-lived, highly active ’super immune cells‘ with strong antitumor activity, according to new research.

Quelle: Sciencedaily

Helicates meet Rotaxanes to create promise for future disease treatment

A new approach to treating cancers and other diseases that uses a mechanically interlocked molecule as a ‚magic bullet‘ has been designed.

Quelle: Sciencedaily

Discovery illuminates how cell growth pathway responds to signals

A basic science discovery reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies.

Quelle: Sciencedaily

Altered ‚coat‘ disguises fatal brain virus from neutralizing antibodies

A genetic modification in the ‚coat‘ of a brain infection-causing virus may allow it to escape antibodies, according to researchers. They say testing people for this and other viral mutations may help identify patients at risk for developing a fatal brain disease.

Quelle: Sciencedaily

How tissue geometry influences the movement of cells through the body

Cells move constantly throughout our bodies, performing myriad operations critical to tissue development, immune responses and general wellbeing. This bustle is guided by chemical cues long studied by scientists interested in cellular migration.

Quelle: Sciencedaily

Getting it just right, the Goldilocks model of cancer

Cancer is a disease driven by mutations that alter the way biochemical signals control cell growth, division and migration. Scientists found out that, like Goldilocks, cancer is very picky about getting rapid growth just right.

Quelle: Sciencedaily

Insights in the search for new antibiotics

A collaborative research team published an opinion article that addresses the gap in the discovery of new antibiotics.

Quelle: Sciencedaily

Ovarian cancer cells cooperate to metastasize

In a study on human ovarian cancer cells in mice, researchers discovered a transient, cooperative interaction between cell subpopulations that allows otherwise nonmetastatic tumor cells to become aggressive and spread.

Quelle: Sciencedaily

Brain protein could be starting point for new treatments for pancreatic cancer

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer. Their findings demonstrate for the first time how the protein, called Netrin-G1, helps pancreatic cancer cells survive by protecting them from the immune system and supplying them with nutrients.

Quelle: Sciencedaily

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells

Researchers have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries a genetic messenger (messenger RNA), which encodes for the CRISPR enzyme Cas9 that acts as molecular scissors that cut the cells‘ DNA.

Quelle: Sciencedaily

A DNA-based nanogel for targeted chemotherapy

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within cancer cells, minimizing the impacts on normal ones and potentially eliminating painful and uncomfortable side effects.

Quelle: Sciencedaily

Killing cancer naturally: New process to produce compounds with anti-cancer properties

Scientists have made a breakthrough in the development of potential drugs that can kill cancer cells. They have discovered a method of synthesizing organic compounds that are four times more fatal to cancer cells and leave non-cancerous cells unharmed. Their research can assist in the creation of new anticancer drugs with minimal side effects.

Quelle: Sciencedaily