Researchers have developed a novel vaccine consisting of DNA and recombinant proteins — proteins composed of a portion of an HIV protein and another unrelated protein.
Using single-molecule imaging, researchers witness how molecules find and fix damaged DNA.
Scientists have identified 12 distinct types of gene-pair interactions in which varying levels of expression in the two genes correlated with cancer patient survival. The results suggest that genes involved in such paired interactions could provide new targets for cancer therapy.
The enzyme ribonucleotide reductase is a bottleneck for cancer cell growth. Scientists have identified a way of targeting ribonucleotide reductase that may avoid the toxicity of previous approaches, informing focused drug discovery efforts.
Researchers chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies.
Average age at diagnosis in the United States has decreased over the past decade.
A new mechanism for the deactivation of switch proteins has been identified. Switch proteins such as Ras regulate many processes in the body and affect diseases such as cancer.
In a study using yeast cells and data from cancer cell lines, scientists report they have found a potential weak spot among cancer cells that have extra sets of chromosomes, the structures that carry genetic material. The vulnerability, they say, is rooted in a common feature among cancer cells — their high intracellular protein concentrations — that make them appear bloated and overstuffed, and which could be used as possible new targets for cancer treatments.
A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a new study. The findings could help break the logjam in the treatment of this deadly disease, which hasn’t seen a significant medical breakthrough in nearly three decades.
More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses. Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time in studying what happens when DNA methylation is lost in human cells. These findings provide new insight into how changes in DNA methylation contribute to diseases.
Many of the deadliest or most common cancers get the least amount of nonprofit research funding, reports a new study. ‚Embarrassing‘ or stigmatized cancers, like lung and liver, are underfunded. Colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung cancers were all poorly funded compared to how common they are and how many deaths they cause, the study found. In contrast, breast cancer, leukemia, lymphoma and pediatric cancers were all well-funded, respective to their impact on society.
For years, doctors and scientists have known very little about why patients can receive drugs successfully for months, or even years, before developing a drug resistance. Now researchers propose that there is a cellular as well as molecular cause to this phenomenon in colon cancer, with potential application to other similarly aggressive cancers as well.
New research finds that low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells.
A combination of chemotherapy drugs during brain cancer surgery using a biodegradable paste, leads to long-term survival, researchers have discovered.
A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth.
CompCyst, a new test, distinguishes pancreatic cysts that are destined to become cancer and need to be surgically removed from cysts that can be left alone without causing harm. The researchers believe CompCyst has the capacity to substantially reduce unnecessary surgeries for pancreatic cysts.
Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. Scientists now describe a new therapeutic approaches that can possibly be derived from these results.
A new study demonstrates that inhibition of the p38 protein boosts the formation of blood vessels in human and mice colon cancers. Known as angiogenesis, this process is critical in fueling cancer cells, allowing them to grow and to eventually develop metastases.
Researchers have created a device that can determine whether targeted chemotherapy drugs are working on individual cancer patients. The portable device, which uses artificial intelligence and biosensors, is up to 95.9% accurate in counting live cancer cells when they pass through electrodes, according to a new study.
A new biomedical research study finds a transcription factor called Slug contributes to breast cell fitness by promoting efficient repair of DNA damage. The absence of Slug leads to unresolved DNA damage and accelerated aging of breast cells.
A new study describes how researchers wirelessly controlled FGFR1 — a gene that plays a key role in how humans grow from embryos to adults — in lab-grown brain tissue. The ability to manipulate the gene, the study’s authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia.