New clues from fruit flies about the critical role of sex hormones in stem cell control

In one of the first studies addressing the role of sex hormones‘ impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone, ecdysone, drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ.

Quelle: Sciencedaily

Higher fruit, vegetable and whole grain intake linked to lower risk of diabetes

Higher consumption of fruit, vegetables and whole grain foods are associated with a lower risk of developing type 2 diabetes, according to two new studies.

Quelle: Sciencedaily

Study sheds light on how cancer spreads in blood

A new study sheds light on proteins in particles called extracellular vesicles, which are released by tumor cells into the bloodstream and promote the spread of cancer. The findings suggest how a blood test involving these vesicles might be used to diagnose cancer in the future, avoiding the need for invasive surgical biopsies.

Quelle: Sciencedaily

Researchers propose novel approach to limit organ damage for patients with severe COVID-19

In a new paper, researchers propose that controlling the local and systemic inflammatory response in COVID-19 may be as important as anti-viral and other therapies.

Quelle: Sciencedaily

Custom nanoparticle regresses tumors when exposed to light

A unique nanoparticle to deliver a localized cancer treatment inhibits tumor growth in mice, according to researchers.

Quelle: Sciencedaily

A key gene modifies regulatory T cells to fine-tune the immune response

The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens, with when to rein in that army, stopping an onslaught from attacking the body itself. Now, researchers have discovered a way to control regulatory T cells, immune cells that act as a cease-fire signal, telling the immune system when to stand down.

Quelle: Sciencedaily

Engineered killer immune cells target tumors and their immunosuppressive allies

Scientists have engineered natural killer immune cells that not only kill head and neck tumor cells in mice but also reduce the immune-suppressing myeloid cells that allow tumors to evade the immune response.

Quelle: Sciencedaily

Novel protein drives cancer progression

Researchers have discovered a protein that drives the progression of esophageal cancer and liver cancer and it could be a promising target for cancer drug development.

Quelle: Sciencedaily

Compounds halt SARS-CoV-2 replication by targeting key viral enzyme

New research identifies several existing compounds that block replication of the COVID-19 virus (SARS-CoV-2) within human cells grown in the laboratory. The inhibitors all demonstrated potent chemical and structural interactions with a viral protein critical to the virus’s ability to proliferate.

Quelle: Sciencedaily

Getting a grasp on India’s malaria burden

A new approach could illuminate a critical stage in the life cycle of one of the most common malaria parasites.

Quelle: Sciencedaily

Marine algae from the Kiel Fjord discovered as a remedy against infections and skin cancer

Using state-of-the-art approaches coupled with bio- and cheminformatics and machine learning, researchers have succeeded in discovering new, bioactive components of the Baltic Sea Baltic Sea seaweed Fucus vesiculosus and its fungal symbiont against infectious bacteria or skin cancer.

Quelle: Sciencedaily

Discovery of key protein behind cancer relapse and progression can lead to new therapies

Reports show that cancer is the second-highest leading cause of death globally. A recent study by scientists provides new evidence supporting the presence of a key mechanism behind progression and relapse in cancer. The study discusses the role of MBNL1 protein as a biomarker for cancer prognosis, which can lead to the development of new treatment strategies for cancer.

Quelle: Sciencedaily

Glowing dye may aid in eliminating cancer

When a solid cancer is surgically removed, any small piece that is left behind increases the chance of a local recurrence or spread. In a pilot study of dogs with mammary tumors, a disease very similar to human breast cancer, a team found that an injectable dye, which glows under near-infrared light, illuminated cancerous growth in the primary tumor as well as in lymph nodes.

Quelle: Sciencedaily

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells

CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient’s own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they have dramatically broadened the potential targets of this approach – their engineered T-cells attack a variety of solid-tumor cancer cells from humans and mice.

Quelle: Sciencedaily

Researchers destroy cancer cells with ultrasound treatment

An international research team has developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles.

Quelle: Sciencedaily

Novel function of platelets in tumor blood vessels found

Scientists have discovered a hitherto unknown function of blood platelets in cancer. In mouse models, these platelets have proved to help preserve the vascular barrier which makes blood-vessel walls selectively impermeable, thereby reducing the spread of tumor cells to other parts of the body.

Quelle: Sciencedaily

Molecular simulations show how drugs block key receptors

Many pharmaceuticals work by targeting what are known as “G-protein-coupled receptors“. In a new study, scientists describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors. The researchers‘ calculation methods are a vital contribution to future structure-based drug design.

Quelle: Sciencedaily

New class of precision medicine strips cancer of its DNA defenses

A new precision medicine targeting cancer’s ability to repair its DNA has shown promising results in the first clinical trial of the drug class. The new study, designed to test the drug’s safety, found that half of patients given the new drug either alone or with platinum chemotherapy saw their cancer stop growing, and two patients saw their tumours shrink or disappear completely.

Quelle: Sciencedaily

Immune cells infiltrating tumors may play bigger cancer role than previously thought

Researchers uncovered in mice how a molecule involved in cells‘ response to stress determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making this molecule an attractive target for drug development.

Quelle: Sciencedaily

Online program improves insomnia in adolescent and young adult cancer survivors

Researchers show that an online program developed specifically for AYA cancer survivors can significantly alleviate insomnia and improve overall quality of life.

Quelle: Sciencedaily

Vitamin D may help prevent a common side effect of anti-cancer immunotherapy

published in CANCER indicates that taking vitamin D supplements may help prevent a potentially serious side effect of a revolutionary form of anti-cancer therapy.

Quelle: Sciencedaily

This enigmatic protein sculpts DNA to repair harmful damage

Sometimes, when something is broken, the first step to fixing it is to break it even more. Scientists have discovered this is the case for a DNA-repairing enzyme that marks then further breaks damaged DNA. Their surprising findings have provided much-needed insight into how DNA repair works in healthy cells, as well as how different mutations can translate into different diseases and cancer.

Quelle: Sciencedaily

Shining light on a malignant lung cancer

Treating a rare type of malignant lung cancer could improve, thanks to near-infrared irradiation and a cancer-targeting compound.

Quelle: Sciencedaily

Renewed hope for treatment of pain and depression

Researchers have developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides produced in the central nervous system (CNS) and potentiating their natural painkilling and antidepressant properties.

Quelle: Sciencedaily

Nanoparticle for overcoming leukemia treatment resistance

One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. A research team found that repurposing a commonly used chemotherapy drug using a nanoparticle was more effective than both a solution of the pure drug and other available treatments.

Quelle: Sciencedaily