Men with breast cancer face high mortality rates

Men with breast cancer are more likely to die than their female counterparts, across all stages of disease, with the disparity persisting even when clinical characteristics, such as cancer types, treatment and access to care are considered, according to a new study.

Quelle: Sciencedaily

New drug-delivery technology promises efficient, targeted cancer treatment

A precise and non-toxic treatment that targets lung cancer cells at the nanoscale is able to effectively kill the cells even at a low dose.

Quelle: Sciencedaily

Novel agent flips on garbage disposal in neurons, eliminating toxic brain proteins in mice

Neuroscientists say they have developed and tested an agent that reduces the buildup of toxic proteins in animal models of both Parkinson’s and Alzheimer’s diseases, and improves cognitive and motor behavior.

Quelle: Sciencedaily

Marked slowdown of cell division rates in old age

In a novel study comparing healthy cells from people in their 20s with cells from people in their 80s, researchers say they have documented that cell division rates appear to consistently and markedly slow down in humans at older ages.

Quelle: Sciencedaily

Machine learning’s next frontier: Epigenetic drug discovery

Scientists have developed a machine-learning algorithm that gleans information from microscope images — allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental illness and more.

Quelle: Sciencedaily

Exploring the effect of fasting on age-related diseases

There are many indications that fasting promotes longevity. In recent years, much attention has been devoted to so-called caloric restriction mimetics (CMRs), substances that simulate the health-promoting effects of fasting without the need of life-style change. A study reports the identification of a novel candidate CRM. The substance may prove useful in the further research for the treatment of age-related diseases.

Quelle: Sciencedaily

Breaking the stroma barrier: Study shows a new way to hit cancer with radiation

Chemotherapy and radiation therapy are commonly used to treat cancer, but are not always effective and can have toxic side effects. Researchers tested a new radiotherapy technique that sends alpha-emitting particles to stroma cells in pancreatic tumors. The method slowed tumor growth in mice with minimal side effects, pointing to a new potential treatment option in the future for patients with pancreatic cancer.

Quelle: Sciencedaily

HPV immunization program cuts pre-cancer rates by more than half

A school-based human papillomavirus (HPV) immunization program in British Columbia, Canada, is dramatically reducing rates of cervical pre-cancer in B.C. women, according to a new study.

Quelle: Sciencedaily

The art of cancer caregiving: How art therapies benefits those caring for cancer patients

A recent study showed coloring and open-studio art therapy benefits stressed caregivers of cancer patients.

Quelle: Sciencedaily

Creatine powers T cells‘ fight against cancer

The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.

Quelle: Sciencedaily

A compound effective to chemotherapy-resistant cancer cells identified

A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.

Quelle: Sciencedaily

A simpler way to make some medicines

Organic chemists have figured out how to synthesize the most common molecule arrangement in medicine, a scientific discovery that could change the way a number of drugs — including one most commonly used to treat ovarian cancer — are produced. Their discovery, published today in the journal Chem, gives drug makers a crucial building block for creating medicines that, so far, are made with complex processes that result in a lot of waste.

Quelle: Sciencedaily

Financial hardship in cancer: The role of health insurance literacy

A new study links health insurance literacy with medical financial hardship as well as non-medical financial sacrifices among adult cancer survivors in the United States.

Quelle: Sciencedaily

A new approach to tackle superbugs

Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients.

Quelle: Sciencedaily

New insights into the structure and function of Cdc34, a target for cancer therapeutics

Researchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.

Quelle: Sciencedaily

Digital breast tomosynthesis increases cancer detection over full-field mammography

A new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in ’significantly increased CDR‘ — irrespective of tumor type, size, or grade of cancer.

Quelle: Sciencedaily

New marker for tumor aggression in neurofibromatosis type 1

A new study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1. According to the researchers, the clues could advance the search for more customized and relevant treatments that spare patients exposure to treatments unlikely to work.

Quelle: Sciencedaily

Pioneering cell therapies for non-responders to current immunotherapies

New research signposts a new, less invasive approach to identify killer T lymphocytes in patients with gastrointestinal tumors with low mutational burden who are refractory to approved immune-based treatments.

Quelle: Sciencedaily

Oxygen in hyperbaric chamber provides relief after radiotherapy

Hyperbaric oxygen therapy (HBOT) can relieve self-reported symptoms and side-effects of radiotherapy against cancer in the pelvic region, a study shows. After 30-40 sessions in a hyperbaric chamber, many patients experienced reductions in bleeding, urinary incontinence, and pain alike.

Quelle: Sciencedaily

Protein misfolding as a risk marker for Alzheimer’s disease

In symptom-free individuals, the detection of misfolded amyloid-beta protein in the blood indicated a considerably higher risk of Alzheimer’s disease — up to 14 years before a clinical diagnosis was made. Amyloid-beta folding proved to be superior to other risk markers evaluated.

Quelle: Sciencedaily

Progress in global cancer fight is not only possible, but achievable

The Cancer Atlas, 3rd edition, a comprehensive global overview of cancer around the globe, concludes that progress in the fight against cancer is not only possible, but achievable.

Quelle: Sciencedaily

Machine learning tool refines personalized immunotherapy

Scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.

Quelle: Sciencedaily

New method for quicker and simpler production of lipidated proteins

The new method is leading to a better understanding of natural protein modifications and improved protein therapeutics.

Quelle: Sciencedaily

‚Back in time‘: Researchers unravel early makings of an exhausted T cell

Researchers explore the path to T-cell exhaustion and what triggers it is.

Quelle: Sciencedaily

DNA fracturing rewires gene control in cancer

A multi-institutional team has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

Quelle: Sciencedaily