Biologists create better method to culture cells for testing drug toxicity

Researchers have discovered that by changing two components of the media used to culture the cells, they can make liver cancer cells behave more like normal liver cells. Rather than using standard serum containing glucose, they used serum from which the glucose had been removed using dialysis and added galactose to the media. This changes the metabolism of the cells making them behave more like normal liver cells.

Quelle: Sciencedaily

Novel hydrogel carriers for anti-cancer drugs offer new hope for cancer treatment

Hydrogels are often used as drug delivery systems, but to be effective carriers for anti-cancer drugs, they need to be responsive to varied stimuli in the tumor microenvironment. Now, scientists have developed novel hydrogels to effectively deliver drugs to tumor sites in response to temperature and pH changes in the tumor microenvironment. These multi-stimuli-responsive hydrogels can eliminate remnant cancer cells following tumor excision through controlled drug release, offering hope for effective cancer treatment.

Quelle: Sciencedaily

Bespoke neuroblastoma therapy weaponizes cell metabolism

Preclinical research shows that the combination of two existing drugs can exploit the metabolic’hunger‘ of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue.

Quelle: Sciencedaily

Engineering a cancer-fighting virus

An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to researchers.

Quelle: Sciencedaily

Cancer has a biological clock and this drug may keep it from ticking

Scientists find and test a promising drug that stops cancer by interfering with the cancer cells‘ metabolism and other circadian-related functions.

Quelle: Sciencedaily

Energizing the immune system to eat cancer

Researchers say they’ve identified how to fuel macrophages with the energy needed to attack and eat cancer cells.

Quelle: Sciencedaily

New mechanism to ‚activate‘ the immune system against cancer

A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, and most effectively in lung cancer and melanoma. (Mehr in: Cancer News — ScienceDaily)

Cancer cells steer a jagged path

Researchers define the role of a jagged ligand, JAG1, in cancer cells‘ ability to differentiate and metastasize, making them harder to track down and eliminate. (Mehr in: Cancer News — ScienceDaily)

Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Consumption of processed foods high in sugar and fat increase levels of advanced glycation end products (AGEs). Researchers report that AGE levels are higher in patients with estrogen receptor (ER)-positive than ER-negative breast cancer. Addition of AGEs caused breast cancer cells, whose growth had previously been controlled by tamoxifen, to begin to grow again. This suggests that patients with high AGEs may be less likely to respond to tamoxifen treatment. (Mehr in: Cancer News — ScienceDaily)

Scientists synthesize molecule capable of eliminating hepatitis C virus

The compound called GA-Hecate also acts on bacteria, fungi and cancer cells and will be tested against Zika and yellow fever viruses. (Mehr in: Cancer News — ScienceDaily)

Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers two years ago. In a follow-up study, scientists report that this drug cocktail induces cancer cell death by switching off their energy supply. (Mehr in: Cancer News — ScienceDaily)

Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer cells distinguished by artificial intelligence-based system

A research team has created a system that uses a convolutional neural network to learn the features distinguishing different cancer cells, based on images from a phase-contrast microscope. This system accurately differentiated human and mouse cancer cells, as well as their radioresistant clones. This novel approach can improve the speed and accuracy of cancer diagnosis by avoiding the laboriousness and potential errors associated with equivalent analyses by humans. (Mehr in: Cancer News — ScienceDaily)

Combination immunotherapy shows high activity against recurrent Hodgkin lymphoma

A new combination of three drugs that harness the body’s immune system is safe and effective, destroying most cancer cells in 95 percent of patients with recurrent Hodgkin lymphoma, according to new results. (Mehr in: Cancer News — ScienceDaily)

New drug combination could be more effective against melanoma

A new study suggests that combining kinase inhibitors with experimental drugs known as ribonucleases could lead to better results. In tests with human cancer cells, the researchers found that the two drugs given together kill cells much more effectively than either drug does on its own. The combination could also help to prevent tumors from developing drug resistance. (Mehr in: Cancer News — ScienceDaily)

When good macrophages go bad

Researchers have discover how some cancer cells communicate with macrophages to protect tumors. (Mehr in: Cancer News — ScienceDaily)

How skin cancer cells sidestep the immune system

Researchers have discovered a new signal pathway employed by skin cancer cells to avoid attack by the immune system. In an animal model and through analysis of human tissue samples, researchers were able to demonstrate the significant role played by a specific protein called ICER. Tumors grow less rapidly when ICER is not present. (Mehr in: Cancer News — ScienceDaily)

Checkmating tumors

Chess and cancer research have one thing in common: one must act strategically to defeat the opponent. And that’s exactly what scientists are doing. They are seeking to selectively make only those cancer cells aggressive that would otherwise evade chemotherapy — and then lure them into a trap. (Mehr in: Cancer News — ScienceDaily)

Fine-tuning cell death: New component of death machinery revealed

An important component of the microscopic machinery that drives cell death has been identified by scientists. Studying the ‚pro-death‘ machinery that forces damaged, diseased or unwanted cells to die, the research team revealed a protein called VDAC2 was critical for the function of a key pro-death protein called Bax. The team also showed VDAC2 contributed to the killing of certain cancer cells by anti-cancer agents. (Mehr in: Cancer News — ScienceDaily)

Cutting the legs off cancer

Melanoma skin cancer tumors grow larger and are more likely to metastasize due to interactions between a pair of molecules, according to experiments in mice and human cells. The results may restore the potential for a type of cancer therapy previously abandoned in clinical trials. The results also implicate one molecule already connected to obesity and dementia as a potential cause of metastasis, or spread of cancer cells to other areas of the body. (Mehr in: Cancer News — ScienceDaily)

Vine Compound Starves Cancer Cells

Researchers from Würzburg and Toyama have discovered that a compound isolated from tropical rainforest vines inhibits the growth of pancreatic cancer cells in the lab. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Rainforest vine compound starves pancreatic cancer cells

Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as ‚austerity.‘ The cells‘ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong “antiausterity“ potential, making pancreatic cancer cells susceptible to nutrient starvation. (Mehr in: Cancer News — ScienceDaily)

Defective DNA damage repair leads to chaos in the genome

Scientists have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation and defective assembly of the genetic material. Cancer cells with such a repair defect can now possibly be treated by a specific group of drugs. (Mehr in: Cancer News — ScienceDaily)

Decrease in specific gene ’silencing‘ molecules linked with pediatric brain tumors

Experimenting with lab-grown brain cancer cells, researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas. (Mehr in: Cancer News — ScienceDaily)

What do metastatic cancer cells have in common with sharks?

In a new study, researchers report that when cancer cells become invasive (metastatic), they start behaving in ‚predatory‘ ways. Metastatic cancer cells differ from their non-metastatic counterparts not only in their genetics, but also in their moving strategy: they spread more rapidly and are more directional than non-invasive cancer cells. (Mehr in: Cancer News — ScienceDaily)