Schlagwort: breast cancer
Changes in lung tissue indicate preparation for supporting the growth of disseminated breast cancer cells
5. August 2021
A new study has revealed changes in healthy lung tissue which indicate preparation to receive metastases. The changes were identified in the area known as ‚the micro-environment‘ of the tumor, and specifically in connective tissue known as fibroblasts.
Statins may improve survival for triple-negative breast cancer patients
4. August 2021
A new study found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.
Seeking a unique treatment for lobular breast cancer
29. Juli 2021
In an attempt to find out why the long-term outcomes are poorer for patients with lobular breast cancer — which affects some 40,000 women a year — researchers began looking at the role of the protein MDC1 in tumor cells.
Maternal diets rich in Omega-3 fatty acids may protect offspring from breast cancer, study suggests
29. Juni 2021
Researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns.
Cholesterol metabolite induces production of cancer-promoting vesicles
10. Juni 2021
Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.
New findings offer improved therapy of early-stage, BRCA mutation-associated breast cancer
5. Juni 2021
A new treatment has potential to improve the outcomes for patients with hereditary BRCA mutations and high-risk, early-stage breast cancer. These results represent the first time a PARP inhibitor has been shown to significantly reduce the risk of breast cancer returning in high-risk patients following completion of standard chemotherapy, surgery and radiation therapy.
The micro-environment of breast cancer in three dimensions
5. Mai 2021
Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells. Now, researchers have developed a way to study the relationship between solid, difficult-to-treat tumors and the microenvironment they create to support their growth.
Review summarizes known links between endocrine disruptors and breast cancer risk
21. April 2021
Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research. However, for many chemicals, evidence is inconsistent or still limited.
A leap forward in research on CAR T cell therapy
22. März 2021
A study looked into how CAR T immunotherapy could be used to treat solid tumors in addition to leukemias. The programming of CAR T cells opens avenues for applying cell therapies to, for example, breast cancer or ovarian cancer in the future.
Exposure to common chemical during pregnancy may reduce protection against breast cancer
21. März 2021
Low doses of propylparaben – a chemical preservative found in food, drugs and cosmetics – can alter pregnancy-related changes in the breast in ways that may lessen the protection against breast cancer that pregnancy hormones normally convey, according to new research.
Breast cancer: The risks of brominated flame retardants
13. März 2021
Brominated flame retardants may lead to early mammary gland development, which is linked to an increased risk of breast cancer.
Making the role of AI in medicine explainable
10. März 2021
Researchers have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). For the first time, morphological, molecular and histological data are integrated in a single analysis. Furthermore, the system provides a clarification of the AI decision process in the form of heatmaps.
What to do when a mammogram shows swollen lymph nodes in women just vaccinated for COVID
27. Februar 2021
When women undergo breast imaging shortly after receiving a COVID-19 vaccine in the arm, their tests may show swollen lymph nodes in the armpit area. Radiologists say that this is usually a normal finding, and if there are no other concerns, no additional imaging tests are needed unless the lymph nodes remain swollen for more than six weeks after vaccination. The team has published an approach to help avoid delays in both vaccinations and breast cancer screening.
Drug is promising against pancreatic and breast cancers
11. Februar 2021
The drug is effective at treating pancreatic cancer and prolonging survival in mice, according to a new study. A second study shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Clinical trials are set to begin in 2021.
Halt cell recycling to treat cancer
9. Februar 2021
Targeting and changing autophagy, otherwise known as cell recycling, has been linked to helping control or diminish certain cancers. Now, researchers have shown that completely halting this process in a very aggressive form of breast cancer may improve outcomes for patients one day.
Popular breast cancer drugs don’t work the way we thought they did
4. Februar 2021
New research suggests that a class of drugs called PARP inhibitors, designed to treat hereditary forms of ovarian and breast cancer, don’t work the way we thought they did. It also paints a fuller picture of how they work, opening the door to improvements in next-generation drugs.
Imaging identifies breast cancer patients unlikely to benefit from hormone therapy
3. Februar 2021
Hormone therapy can be very effective for so-called estrogen receptor-positive breast cancer. But it only works for a little more than half of women who receive the treatment. In a small study, researchers found that women whose tumors did not respond to a one-day estrogen challenge did not benefit from hormone therapy. The findings could help doctors choose treatments most likely to help their patients.
New discovery in breast cancer treatment
20. Januar 2021
Researchers have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.
Statins may protect the heart from chemotherapy treatment of early breast cancer
7. Januar 2021
Women who take statins, the common cholesterol-lowering medication, during chemotherapy with anthracyclines for early-stage breast cancer are half as likely to require emergency department visits or hospitalization for heart failure in the 5 years after chemotherapy.
A global assessment of cancer genomic alterations in epigenetic mechanisms
5. März 2015
Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira
Abstract
Background
The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.
Results
Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.
Conclusions
This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.
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