Shared genetic marker offers new promise in targeting specific ovarian and lung cancers

Two new articles offer promise that a drug currently used to treat estrogen positive breast cancer may be effective in treating two different types of cancer, one rare and one common form.

Quelle: Sciencedaily

Many women get unnecessary mammograms before breast reduction surgery

Getting a mammogram before breast reduction surgery is not required or recommended. But thousands of younger women with no known breast cancer risk still get them, a new study shows.

Quelle: Sciencedaily

Genetic testing does not cause undue worry for breast cancer patients

As genetic testing for breast cancer has become more complex, evaluating a panel of multiple genes, it introduces more uncertainty about the results. But a new study finds that newer, more extensive tests are not causing patients to worry more about their cancer risk. (Mehr in: Cancer News — ScienceDaily)

Experimental treatment shows promise against triple-negative breast cancer

A naturally occurring protein called Tinagl1 reduced the spread of triple-negative breast cancer in a study conducted in mice. (Mehr in: Cancer News — ScienceDaily)

Persistent hot flashes may lead to increased risk of breast cancer

Studies examining the association between vasomotor symptoms (VMS) and breast cancer are not new, but results have been inconsistent. A new larger-scale study concludes that women participating in the Women’s Health Initiative (WHI) trials who had persistent VMS are more likely to be diagnosed with breast cancer than women who never experienced VMS. (Mehr in: Cancer News — ScienceDaily)

Tumors backfire on chemotherapy

Chemotherapy is an effective treatment for breast cancer, yet some patients develop metastasis in spite of it. Researchers have now discovered that chemotherapy-treated mammary tumors produce small vesicles that may help them spread to other organs. (Mehr in: Cancer News — ScienceDaily)

Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Consumption of processed foods high in sugar and fat increase levels of advanced glycation end products (AGEs). Researchers report that AGE levels are higher in patients with estrogen receptor (ER)-positive than ER-negative breast cancer. Addition of AGEs caused breast cancer cells, whose growth had previously been controlled by tamoxifen, to begin to grow again. This suggests that patients with high AGEs may be less likely to respond to tamoxifen treatment. (Mehr in: Cancer News — ScienceDaily)

Confronting the side effects of a common anti-cancer treatment

Results of a new study suggest that a new treatment approach is needed — and how this may be possible — to address adverse effects of aromatase inhibitors, drugs commonly prescribed to both men and women to prevent recurrence of estrogen-positive breast cancer. (Mehr in: Cancer News — ScienceDaily)

Breast cancer drugs could help treat resistant lung cancers

A class of drugs used to treat certain breast cancers could help to tackle lung cancers that have become resistant to targeted therapies, a new study suggests. The research found that lung tumors in mice caused by mutations in a gene called EGFR shrunk significantly when a certain protein was blocked. (Mehr in: Cancer News — ScienceDaily)

How breast cancer avoids immune system detection

Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based on the immune evasion mechanisms that breast cancer uses to avoid detection. (Mehr in: Cancer News — ScienceDaily)

Increased risk for breast cancer after childbirth may last more than 20 years

The increased risk for breast cancer that occurs after childbirth can last more than 20 years. The risk may be enhanced when a woman is older at first birth or has a family history of breast cancer, and is not mitigated by breastfeeding. (Mehr in: Cancer News — ScienceDaily)

New imaging tools that trace key breast cancer enzymes may help guide therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers. (Mehr in: Cancer News — ScienceDaily)

Women reveal the reasons they reject a preventive drug for breast cancer

Only around a fifth of women at higher risk of developing breast cancer think they need to take a drug proven to help prevent the disease, according to new research. (Mehr in: Cancer News — ScienceDaily)

How much do you trust Dr. Google?

Women experiencing signs of breast cancer vary in how they value, use, and trust ‚Dr. Google‘ when making sense of their symptoms, a new study reports. (Mehr in: Cancer News — ScienceDaily)

Cancer treatments may affect cognitive function by accelerating biological aging

Cancer treatments are suspected to accelerate certain aging processes in the body. A new study has found that indicators of such biological aging correlate with declines in cognitive function in women who had undergone breast cancer treatment several years earlier. The findings point to an aging-like effect of cancer treatments and further connect this to cognitive decline. (Mehr in: Cancer News — ScienceDaily)

Women benefit from mammography screening beyond age 75

Women age 75 years and older should continue to get screening mammograms because of the comparatively high incidence of breast cancer found in this age group, according to a new study. (Mehr in: Cancer News — ScienceDaily)

A molecule for fighting muscular paralysis

Myotubular myopathy is a severe genetic disease that leads to muscle paralysis. Although no treatment currently exists, researchers have identified a molecule that not only greatly reduces the progression of the disease but also boosts life expectancy in animal models by a factor of seven. Since the molecule — known as tamoxifen — is already used for breast cancer, the researchers hope to soon set up a clinical trial. (Mehr in: Cancer News — ScienceDaily)

Hidden estrogen receptors in breast epithelium

Scientists have uncovered that next to estrogen receptor positive and negative there are cells with very low amounts of the receptor protein. The discovery has significant implications for the role of the receptor in the growth and development of the breast and breast cancer development. (Mehr in: Cancer News — ScienceDaily)

Women who are ‚larks‘ have a lower risk of developing breast cancer

Women who are ‚larks‘, functioning better at the beginning of the day than the end of the day, have a lower of risk breast cancer, according to new research. (Mehr in: Cancer News — ScienceDaily)

Breast cancer cells become invasive by changing their identity

Researchers have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis. (Mehr in: Cancer News — ScienceDaily)

Targeting cancer

The complex tumour structure makes the treatment of breast cancer a medical challenge. A promising, novel selenium-based breast cancer nanoparticle therapy by the Austrian Centre of Industrial Biotechnology (acib) together with other partners in the EU-project Neosetac could change that: It has proved to boost the active agent delivery and assure it’s active only in the target tissue while also bringing the suggestion of reduced side effects. The project findings are expected to increase the efficiency of future chemotherapies and prevent recurrence of the cancer after complete remission. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Small risks may have big impact on breast cancer odds of childhood cancer survivors

Scientists found that the combined effect of common genetic variations can dramatically increase risk of breast cancer for female pediatric cancer survivors. (Mehr in: Cancer News — ScienceDaily)

Device created to deliver immunotherapy without side effects

Scientists have developed a nanodevice to deliver immunotherapy without side effects to treat triple-negative breast cancer. Inserted straight into a tumor, this device makes it possible to deliver a one-time, sustained-release dose that would eliminate the need for patients to undergo several IV treatments over time. (Mehr in: Cancer News — ScienceDaily)

Actin cytoskeleton remodeling protects tumor cells against immune attack

Cancer cells have evolved multiple escape strategies to circumvent the body’s immune defenses such as the attack by Natural Killer (NK) cells which normally swiftly kill abnormal cells by releasing cytotoxic products. While studying breast cancer cell lines, scientists have uncovered a previously unknown mechanism that leaves tumor cells unharmed by NK cell-mediated cytotoxicity. (Mehr in: Cancer News — ScienceDaily)

Automated system identifies dense tissue, a risk factor for breast cancer, in mammograms

Researchers have developed an automated model that assesses dense breast tissue in mammograms — which is an independent risk factor for breast cancer — as reliably as expert radiologists. This marks the first time a deep-learning model of its kind has successfully been used in a clinic on real patients, according to the researchers. With broad implementation, the researchers hope the model can help bring greater reliability to breast density assessments across the nation. (Mehr in: Cancer News — ScienceDaily)