New research has uncovered a surprising role for so-called ‚jumping‘ genes that are a source of genetic mutations responsible for a number of human diseases. Scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers.
Researchers have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers.
Researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction.
Powerful algorithms can ‚predict‘ the biological language of cancer and neurodegenerative diseases like Alzheimer’s, scientists have found. Big data produced during decades of research was fed into a computer language model to see if artificial intelligence can make more advanced discoveries than humans.
Researchers have discovered that by changing two components of the media used to culture the cells, they can make liver cancer cells behave more like normal liver cells. Rather than using standard serum containing glucose, they used serum from which the glucose had been removed using dialysis and added galactose to the media. This changes the metabolism of the cells making them behave more like normal liver cells.
Researchers have discovered a direct link between a master sensor of cell stress and a protein that protects the power stations of cells. The same pathway is also tied to type 2 diabetes and cancer, which could open a new avenue for treating all three diseases.
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion.
Hydrogels are often used as drug delivery systems, but to be effective carriers for anti-cancer drugs, they need to be responsive to varied stimuli in the tumor microenvironment. Now, scientists have developed novel hydrogels to effectively deliver drugs to tumor sites in response to temperature and pH changes in the tumor microenvironment. These multi-stimuli-responsive hydrogels can eliminate remnant cancer cells following tumor excision through controlled drug release, offering hope for effective cancer treatment.
Scientists has illuminated the functions of mysterious structures in cells called ’nuclear speckles,‘ showing that they can work in partnership with a key protein to enhance the activities of specific sets of genes.
Researchers have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data.
Preclinical research shows that the combination of two existing drugs can exploit the metabolic’hunger‘ of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue.
Researchers have identified nine potential new COVID-19 treatments, including three that are already approved by the U.S. Food and Drug Administration for treating other diseases. The team screened thousands of existing drugs and drug-like molecules for their ability to inhibit the replication of the COVID-19-causing coronavirus, SARS-CoV-2.
Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. Scientists demonstrates the importance of a molecule called beta-catenin in striking this balance.
Researchers have uncovered a long-sought link in the battle to control cholesterol and heart disease. The protein that interferes with low-density lipoprotein (LDL) receptors that clear ‚bad‘ cholesterol from the blood was identified. Excess LDL cholesterol can lead to atherosclerosis — a narrowing and hardening of arteries — and ultimately, heart attack.
A research team is building new lymphatic cord-like structures, which help restore normal behavior to dysfunctional lymphatic systems and allow the body to fight the disease.
An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study suggests that a minor adjustment to the current standard treatment — giving chemotherapy in the morning rather than the evening — could add a few months to patients‘ survival.
Emerging technologies can screen for cervical cancer better than Pap smears and, if widely used, could save lives in areas where access to health care may be limited. In Biophysics Reviews, scientists at Massachusetts General Hospital write advances in nanotechnology and computer learning are among the technologies helping develop HPV screening that take the guesswork out of the precancer tests. That could mean better screening in places that lack highly trained doctors and advanced laboratories.
Comorbidities such as heart disease, respiratory disease, renal disease and cancer lead to an increased risk of death from COVID-19, according to new research.
Research finds that a specific strain of herpesvirus triggers cervical cancer affecting nearly 1 in 4 necropsied California sea lions. The findings show that sea lions are a critical model for understanding how cancer develops with important parallels to human cancer research.
One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood the cancer could spread, a study has shown.
Researchers use mathematical modeling to help explain why CAR T cells work in some patients and not in others.
A combination of esophageal brushing and extensive genetic sequencing of the sample collected can detect chromosome alterations in people with Barrett’s Esophagus, identifying patients at risk for progressing to esophageal cancer, according to a new study.
Because Taspase 1 dysregulation is increasingly implicated in the genesis and metastasis of various cancers, it has become an attractive candidate for drug development. But before this can happen, researchers will need a highly detailed blueprint of the structure of this protease. In a new study appearing in the Cell Press journal Structure, researchers from Arizona State University describe their investigations, which reveal the structure of Taspase 1 as never before.