Biologic age, a DNA-based estimate of a person’s age, is associated with future development of breast cancer, according to scientists. Biologic age was determined by measuring DNA methylation, a chemical modification to DNA that is part of the normal aging process. For every five years a woman’s biologic age was older than her chronologic or actual age, she had a 15 percent increased risk of developing breast cancer.
Researchers are parsing how the retina hijacks an energy-producing chemical reaction to churn out molecular building blocks to renew photoreceptor membranes that keep our vision sharp.
Previous studies have shown that estrogens and estrogen-like compounds reduce multiple sclerosis-like inflammation and disability in mice. At first glance these treatments appear promising, but they carry a host of negative side effects, from feminizing male mice to increasing the risk of cancer, heart disease and stroke. An interdisciplinary team of scientists have piggy-backed on this approach with a new concept that side steps the negative side effects while alleviating symptoms.
A new study suggests that high-fat diets fuel colorectal cancer growth by upsetting the balance of bile acids in the intestine and triggering a hormonal signal that lets potentially cancerous cells thrive. The findings could explain why colorectal cancer, which can take decades to develop, is being seen in younger people growing up at a time when higher-fat diets are common.
A new article outlines novel design guidance that could rapidly advance development of disease-sensing nanomaterials for use in new drug development.
Spouses can help breast cancer patients with coping by positively reframing the cancer experience and other negative experiences. In general, positive reframing — finding the silver lining — was associated with less stress. Researchers suggest the findings can be extended to a broader population.
Consumption of allium vegetables — which include garlic, leeks, and onions — was linked with a reduced risk of in colorectal cancer in a study of men and women in China.
Melanoma tumors that have spread to the brain are equipped to thwart immunotherapies and targeted therapies that succeed against tumors growing in other sites. Researchers report that the heavy reliance of these tumors on a specific metabolic pathway presents a potentially new therapeutic against these lethal tumors.
In a strategic search, scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.
Healthy T-cells play a crucial role in how the body fights follicular lymphoma, according to a new study. T-cells are a key part of the immune system and protect the body by fighting infections and cancer.
Infections with a Human Papillomavirus (HPV) cause 99 percent of cervical cancer cases, and the disease’s first sign is often the appearance of precancerous lesions on a woman’s cervix. But bacteria may play an important role, too. New research suggests that the cervical microbiome may influence HPV infection more than researchers previously thought.
Researchers have identified a very early marker of cardiac damage in patients undergoing therapy with anthracyclines, a family of drugs commonly used to treat cancer. This finding will enable the early diagnosis of the cardiotoxicity associated with this group of widely used chemotherapy drugs.
Scientists discovered a previously unknown trigger that turns run-of-the-mill strep infections into the flesh-eating disease childbed fever, which strikes postpartum moms and newborns, often leaving victims without limbs. Using an unprecedented approach, they looked at the interplay between the genome, transcriptome and virulence. This generated a massive data set, lending itself to artificial intelligence analysis. Through AI they unexpectedly discovered a new mechanism controlling virulence.
Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression. While mutations in cancer cells significantly affect drug sensitivity, it is increasingly recognized that ecological interactions between cells can also play a role.
A combination of two drugs — one of them an immunotherapy agent — could become a new standard, first-line treatment for patients with metastatic kidney cancer, results from a phase 3 clinical trial suggest.
Researchers have discovered a new mechanism for a class of anti-cancer drugs known as E1 inhibitors. Their findings reveal a novel binding site that will promote drug design of more efficient E1 inhibitors.
A new study may resolve a decades-old debate in immunology: researchers report that distinct progenitor cells are not required for the development of B1 cells. Instead, the team’s experiments show that a B1-typical B-cell receptor can reprogram B2 cells into B1 cells, suggesting that B1 cells emerge as a consequence of their special B-cell receptors.
Research has suggested that the efficiency with which we transport oxygen to our tissues (cardiorespiratory fitness) is a far greater predictor of gut microbiota diversity than either body fat percentage or general physical activity.
A cutting-edge technique called cellular barcoding has been used to tag, track and pinpoint cells responsible for the spread of breast cancer from the main tumour into the blood and other organs.
Researchers recently demonstrated that platinum nanoparticles can be used to kill liver cancer cells with greater selectivity than existing cancer drugs.
Survival after a diagnosis of heart failure in the United Kingdom has shown only modest improvement in the 21st century and lags behind other serious conditions, such as cancer, finds a large study.