Antibiotic use linked to heightened bowel cancer risk

Antibiotic use (pills/capsules) is linked to a heightened risk of bowel (colon) cancer, but a lower risk of rectal cancer, and depends, to some extent, on the type and class of drug prescribed, suggests new research.

Quelle: Sciencedaily

Treating dogs with human breast cancer drug

Like many women who develop a particular type of breast cancer, the same gene — HER2 — also appears to be the cause of lung cancer in many dogs. Researchers found that neratinib — a drug that has successfully been used to battle human breast cancer — might also work for many of the nearly 40,000 dogs in the US that annually develop the most common type of canine lung cancer, known as CPAC.

Quelle: Sciencedaily

Novel combination of drugs may overcome drug-resistant cancer cells

A new study suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance.

Quelle: Sciencedaily

A new path to cancer therapy: developing simultaneous multiplexed gene editing technology

Scientists have developed a new gene editing system that could be used for anticancer immunotherapy through the simultaneous suppression of proteins that interfere with the immune system expressed on the surface of lymphoma cells and activation of cytotoxic T lymphocyte.

Quelle: Sciencedaily

Possible new treatment strategy for lung cancer

It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers are hoping to change that. They have now discovered a new treatment approach that may help this group of patients.

Quelle: Sciencedaily

Targeting cell division in pancreatic cancer

Study provides new evidence of synergistic effects of drugs that inhibit cell division and support for further clinical trials.

Quelle: Sciencedaily

New lipid signaling target may improve T cell immunotherapy

T cell immunotherapy uses the immune system to kill cancer cells. To increase the efficacy of this new treatment, researchers aimed to discover a master regulator of T cell fate. The signaling lipid sphingosine 1-phosphate (S1P) influences the T cell lineage: high levels of S1P lead to an inhibitory regulatory T cell phenotype, while low levels of S1P lead to a central memory-like phenotype, which exhibit increased anti-cancer functions.

Quelle: Sciencedaily

Laboratory studies identify a potential way to treat human cancers with ARID1A mutations

A new study shows that tumor cells depleted of ARID1A — a protein that acts as a cancer suppressor — become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, the study team suggests.

Quelle: Sciencedaily

Identification of genes responsible for sex-related differences in cancer aggressiveness

An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments. The study compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness.

Quelle: Sciencedaily

Numbers count in the genetics of moles and melanomas

Scientists have identified a way to help dermatologists determine a patient’s risk of developing melanoma.

Quelle: Sciencedaily

Non-invasive electrical stimulation alters blood flow in brain tumors

Scientists demonstrated that applying low-intensity electrical stimulation to the brains of patients with tumors resulted in decreased blood flow within tumors while leaving the rest of the brain unchanged. Although further study is needed, the findings suggest that a series of such treatments could modify tumor growth and progression.

Quelle: Sciencedaily

New contrast agent could make MRIs safer

Researchers have taken a key step forward in developing a new, possibly safer contrast agent for use in MRI exams.

Quelle: Sciencedaily

How cells override genetic changes

A new discovery could lead researchers to a more effective way to treat pancreatic cancer.

Quelle: Sciencedaily

Mutations linked to familial pancreatic cancer

A new study finds genetic mutations associated with hereditary forms of pancreatic cancer and mechanism by which these mutations may contribute to the development of tumors.

Quelle: Sciencedaily

MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy

A study has identified a possible second-line treatment for melanoma patients.

Quelle: Sciencedaily

More cancer cases among women with sleep apnea

Women with severe sleep apnea appear to be at an elevated risk of getting cancer, a study shows. No causal relationship is demonstrated, but the link between nocturnal hypoxia in women and higher cancer risk is still clear.

Quelle: Sciencedaily

Nanoparticle therapy targets lymph node metastases

Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients. The lymph nodes — glands of the immune system located throughout the body — are typically the traveling cells‘ first destination. Now, researchers have developed a strategy to target metastases in lymph nodes for destruction, before they can cause cancer at other locations.

Quelle: Sciencedaily

Exercise associated with benefit to patients with advanced colorectal cancer

Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to a new study.

Quelle: Sciencedaily

New drug shows encouraging survival in pancreatic cancer

A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers. The trial looked at AZD1775, an inhibitor designed to block an enzyme called Wee1, which plays a role in DNA damage repair.

Quelle: Sciencedaily

Moles on the body largely influenced by genetics, finds new study

A new study has found that genes have a greater influence than previously thought not only on the number of moles you have but also where they are on your body.

Quelle: Sciencedaily

Optimal vitamin D levels may vary for different ethnic and racial groups

When recommending vitamin D supplements, doctors should look at each individual patient as having different requirements and not rely on ‚one-size-fits-all‘ guidelines, according to a new study.

Quelle: Sciencedaily

Flavonoid-rich diet protects against cancer and heart disease, study finds

Consuming flavonoid-rich items such as apples and tea protects against cancer and heart disease, particularly for smokers and heavy drinkers, according to new research.

Quelle: Sciencedaily

Inherited pancreatic cancer risk mutation identified

The discovery of the previously unknown mutation could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3.

Quelle: Sciencedaily

Key to targeting the spread of pancreatic cancer

Targeting the tissue around pancreatic cancer cells may be the key to stopping their spread and improving chemotherapy outcomes.

Quelle: Sciencedaily

Aspirin may help some breast cancer survivors, but changes in DNA may mean harm for others

Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.

Quelle: Sciencedaily