Using sponges to wipe out cancer

Manzamine A, a natural product derived from certain groups of sponges, can block the growth of cervical cancer cells, report researchers. Manzamine A targets a protein that is highly expressed in many cancers, including cervical cancer, and is the first reported inhibitor of this protein.

Quelle: Sciencedaily

To divide or not to divide? The mother cell may decide

Researchers have found that it’s actually the mother cell that determines if its daughter cells will divide. The finding sheds new light on the cell cycle using modern imaging technologies, and could have implications for cancer drug therapy treatments.

Quelle: Sciencedaily

Treating COVID-19 in a patient with multiple myeloma

A case study of a patient in Wuhan, China, suggests that the immunosuppressant tocilizumab may be an effective COVID-19 treatment for very ill patients who also have multiple myeloma and other blood cancers. The report also suggests that blood cancer patients may have atypical COVID-19 symptoms.

Quelle: Sciencedaily

Starving pancreatic cancer of cysteine may kill tumor cells

In a new study of mice, researchers have found that an experimental drug that breaks down the amino acid cysteine slows pancreatic tumor growth by causing ferroptosis, an unusual form of cell death.

Quelle: Sciencedaily

Study overturns ’snapshot‘ model of cell cycle in use since 1974

Live, single-cell imaging shows cellular ‚memory‘ of growth factor availability throughout the cell cycle (and not just snapshot of growth factor availability) influences cells‘ decision to replicate.

Quelle: Sciencedaily

Turning cells into computers with protein logic gates

New artificial proteins have been created to function as molecular logic gates. Like their electronic counterparts in computers, these biochemical tools can be used to program the behavior of complex systems, such as gene regulation inside human T-cells. This new advance might improve the durability of future cell-based therapies.

Quelle: Sciencedaily

Understanding brain tumors in children

The causes of 40% of all cases of certain medulloblastomas — dangerous brain tumors affecting children — are hereditary. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer.

Quelle: Sciencedaily

Blood test detects over 50 types of cancer, some before symptoms appear

In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy, according to an international team of researchers.

Quelle: Sciencedaily

Study helps to identify medications which are safe to use in treatment of COVID-19

A recent study has found that there is no evidence for or against the use of non-steroidal anti-inflammatory drugs such as ibuprofen for patients with COVID-19.

Quelle: Sciencedaily

Hidden messages in protein blueprints

Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In this way, they control the amount of protein produced and can also control the formation of certain proteinisoforms. If this mechanism is inactivated, stem cells lose their self-renewal potential and can no longer react adequately to danger signals or inflammation.

Quelle: Sciencedaily

Researchers find way to improve cancer outcomes by examining patients‘ genes

Genetics researchers say a new approach could benefit all sorts of serious health conditions, and they’re urging scientists to quickly pluck ‚low hanging fruit‘ for the benefit of patients.

Quelle: Sciencedaily

Microbiome may hold key to identifying HPV-infected women at risk for pre-cancer

Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for progression to precancer, according to a new study.

Quelle: Sciencedaily

Disasters can affect cervical cancer screening for years

Screening is important for the early detection of cervical cancer, but rates were significantly affected, in some areas for years, following a devastating earthquake and tsunami in Japan.

Quelle: Sciencedaily

Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively — allowing the nanoparticles to diffuse into tumors and become held in place, or actively — adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice suggests the question is even more complicated.

Quelle: Sciencedaily

Class of compounds capable of killing Candida auris identified

Researchers have discovered that rocaglate compounds are capable of killing Candida auris. The study offers hope of finding a treatment for this troubling, emerging pathogen.

Quelle: Sciencedaily

Despite failures, chemo still promising against dangerous childhood brain cancer, DIPG

The pediatric brain cancer known as diffuse intrinsic pontine glioma (DIPG) is almost uniformly fatal. In part, this is due to where and how it grows, forming as a diffuse net of cells in a part of the brainstem called the pons, which controls essential functions like breathing and swallowing. Another factor that makes DIPG especially dangerous is a lack of treatments – currently, there are no targeted therapies or immunotherapies proven effective to treat the condition, and the many chemotherapy clinical trials seeking to treat DIPG have been uniformly unsuccessful.

Quelle: Sciencedaily

Computational human cell reveals new insight on genetic information processing

Researchers have developed the first computational model of a human cell and simulated its behavior for 15 minutes — the longest time achieved for a biological system of this complexity. In a new study, simulations reveal the effects of spatial organization within cells on some of the genetic processes that control the regulation and development of human traits and some human diseases.

Quelle: Sciencedaily

How trans fats assist cell death

Researchers have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. Their findings implicate their role in enhancing a mitochondrial signalling pathway that leads to programmed cell death.

Quelle: Sciencedaily

Ultrafast repeated staining and destaining of cell samples for tumor diagnostics

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. Scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly (under 1 hour) be cycled through staining, destaining, and then restaining with fluorescent antibodies — through attachment of a “black hole quencher“ (fluorescence quencher) by means of “click chemistry“.

Quelle: Sciencedaily

Engineers model mutations causing drug resistance

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and ’second generation‘ approaches are needed. Now, a team of engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.

Quelle: Sciencedaily

Device could ‚hear‘ disease through structures housing cells

Researchers have built a device that uses sound waves to detect the stiffness of an extracellular matrix, a structural network that contains cells. Changes in the stiffness of this structure can indicate the spread of disease.

Quelle: Sciencedaily

How to manage cancer care during COVID-19 pandemic

Experts share lessons learned from early experiences treating people with cancer during COVID-19 outbreak.

Quelle: Sciencedaily

‚Natural killer‘ cells could halt Parkinson’s progression

Researchers have found that ’natural killer‘ white blood cells could guard against the cascade of cellular changes that lead to Parkinson’s disease and help stop its progression.

Quelle: Sciencedaily

AI taps human wisdom for faster, better cancer diagnosis

A new system combining artificial intelligence (AI) with human knowledge promises faster and more accurate cancer diagnosis. The powerful technology, developed by engineering researchers, uses digital images of tissue samples to match new cases of suspected cancer with previously diagnosed cases in a database.

Quelle: Sciencedaily

Researchers stop blood vessel, tumor growth in mice

Scientists have devised a new strategy to stop tumors from developing the new blood vessels they need to grow. Once thought to be extremely promising for the treatment of cancer, blocking molecules that stimulate new blood vessel growth (angiogenesis) has proven ineffective because tumor cells respond by producing more stimulatory molecules.

Quelle: Sciencedaily