Antibiotic use (pills/capsules) is linked to a heightened risk of bowel (colon) cancer, but a lower risk of rectal cancer, and depends, to some extent, on the type and class of drug prescribed, suggests new research.
Like many women who develop a particular type of breast cancer, the same gene — HER2 — also appears to be the cause of lung cancer in many dogs. Researchers found that neratinib — a drug that has successfully been used to battle human breast cancer — might also work for many of the nearly 40,000 dogs in the US that annually develop the most common type of canine lung cancer, known as CPAC.
A new study suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance.
Scientists have developed a new gene editing system that could be used for anticancer immunotherapy through the simultaneous suppression of proteins that interfere with the immune system expressed on the surface of lymphoma cells and activation of cytotoxic T lymphocyte.
It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers are hoping to change that. They have now discovered a new treatment approach that may help this group of patients.
T cell immunotherapy uses the immune system to kill cancer cells. To increase the efficacy of this new treatment, researchers aimed to discover a master regulator of T cell fate. The signaling lipid sphingosine 1-phosphate (S1P) influences the T cell lineage: high levels of S1P lead to an inhibitory regulatory T cell phenotype, while low levels of S1P lead to a central memory-like phenotype, which exhibit increased anti-cancer functions.
A new study shows that tumor cells depleted of ARID1A — a protein that acts as a cancer suppressor — become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, the study team suggests.
An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments. The study compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness.
Scientists have identified a way to help dermatologists determine a patient’s risk of developing melanoma.
Scientists demonstrated that applying low-intensity electrical stimulation to the brains of patients with tumors resulted in decreased blood flow within tumors while leaving the rest of the brain unchanged. Although further study is needed, the findings suggest that a series of such treatments could modify tumor growth and progression.
A study has identified a possible second-line treatment for melanoma patients.
Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients. The lymph nodes — glands of the immune system located throughout the body — are typically the traveling cells‘ first destination. Now, researchers have developed a strategy to target metastases in lymph nodes for destruction, before they can cause cancer at other locations.
Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to a new study.
A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers. The trial looked at AZD1775, an inhibitor designed to block an enzyme called Wee1, which plays a role in DNA damage repair.
A new study has found that genes have a greater influence than previously thought not only on the number of moles you have but also where they are on your body.
When recommending vitamin D supplements, doctors should look at each individual patient as having different requirements and not rely on ‚one-size-fits-all‘ guidelines, according to a new study.
Consuming flavonoid-rich items such as apples and tea protects against cancer and heart disease, particularly for smokers and heavy drinkers, according to new research.
The discovery of the previously unknown mutation could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3.
Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.