Manzamine A, a natural product derived from certain groups of sponges, can block the growth of cervical cancer cells, report researchers. Manzamine A targets a protein that is highly expressed in many cancers, including cervical cancer, and is the first reported inhibitor of this protein.
Researchers have found that it’s actually the mother cell that determines if its daughter cells will divide. The finding sheds new light on the cell cycle using modern imaging technologies, and could have implications for cancer drug therapy treatments.
A case study of a patient in Wuhan, China, suggests that the immunosuppressant tocilizumab may be an effective COVID-19 treatment for very ill patients who also have multiple myeloma and other blood cancers. The report also suggests that blood cancer patients may have atypical COVID-19 symptoms.
In a new study of mice, researchers have found that an experimental drug that breaks down the amino acid cysteine slows pancreatic tumor growth by causing ferroptosis, an unusual form of cell death.
Live, single-cell imaging shows cellular ‚memory‘ of growth factor availability throughout the cell cycle (and not just snapshot of growth factor availability) influences cells‘ decision to replicate.
New artificial proteins have been created to function as molecular logic gates. Like their electronic counterparts in computers, these biochemical tools can be used to program the behavior of complex systems, such as gene regulation inside human T-cells. This new advance might improve the durability of future cell-based therapies.
The causes of 40% of all cases of certain medulloblastomas — dangerous brain tumors affecting children — are hereditary. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer.
In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy, according to an international team of researchers.
A recent study has found that there is no evidence for or against the use of non-steroidal anti-inflammatory drugs such as ibuprofen for patients with COVID-19.
Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In this way, they control the amount of protein produced and can also control the formation of certain proteinisoforms. If this mechanism is inactivated, stem cells lose their self-renewal potential and can no longer react adequately to danger signals or inflammation.
Genetics researchers say a new approach could benefit all sorts of serious health conditions, and they’re urging scientists to quickly pluck ‚low hanging fruit‘ for the benefit of patients.
Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for progression to precancer, according to a new study.
Screening is important for the early detection of cervical cancer, but rates were significantly affected, in some areas for years, following a devastating earthquake and tsunami in Japan.
Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer
Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively — allowing the nanoparticles to diffuse into tumors and become held in place, or actively — adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice suggests the question is even more complicated.
Researchers have discovered that rocaglate compounds are capable of killing Candida auris. The study offers hope of finding a treatment for this troubling, emerging pathogen.
The pediatric brain cancer known as diffuse intrinsic pontine glioma (DIPG) is almost uniformly fatal. In part, this is due to where and how it grows, forming as a diffuse net of cells in a part of the brainstem called the pons, which controls essential functions like breathing and swallowing. Another factor that makes DIPG especially dangerous is a lack of treatments – currently, there are no targeted therapies or immunotherapies proven effective to treat the condition, and the many chemotherapy clinical trials seeking to treat DIPG have been uniformly unsuccessful.
Researchers have developed the first computational model of a human cell and simulated its behavior for 15 minutes — the longest time achieved for a biological system of this complexity. In a new study, simulations reveal the effects of spatial organization within cells on some of the genetic processes that control the regulation and development of human traits and some human diseases.
Researchers have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. Their findings implicate their role in enhancing a mitochondrial signalling pathway that leads to programmed cell death.
In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. Scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly (under 1 hour) be cycled through staining, destaining, and then restaining with fluorescent antibodies — through attachment of a “black hole quencher“ (fluorescence quencher) by means of “click chemistry“.
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and ’second generation‘ approaches are needed. Now, a team of engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.
Researchers have built a device that uses sound waves to detect the stiffness of an extracellular matrix, a structural network that contains cells. Changes in the stiffness of this structure can indicate the spread of disease.
Experts share lessons learned from early experiences treating people with cancer during COVID-19 outbreak.
Researchers have found that ’natural killer‘ white blood cells could guard against the cascade of cellular changes that lead to Parkinson’s disease and help stop its progression.
A new system combining artificial intelligence (AI) with human knowledge promises faster and more accurate cancer diagnosis. The powerful technology, developed by engineering researchers, uses digital images of tissue samples to match new cases of suspected cancer with previously diagnosed cases in a database.
Scientists have devised a new strategy to stop tumors from developing the new blood vessels they need to grow. Once thought to be extremely promising for the treatment of cancer, blocking molecules that stimulate new blood vessel growth (angiogenesis) has proven ineffective because tumor cells respond by producing more stimulatory molecules.