Coffee associated with improved survival in metastatic colorectal cancer patients

In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers report in a new study.

Quelle: Sciencedaily

Algorithms uncover cancers‘ hidden genetic losses and gains

Limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes. Now, methods developed by computer scientists will allow researchers to more accurately identify these mutations in cancerous tissue, yielding a clearer picture of the evolution and spread of tumors than was previously possible.

Quelle: Sciencedaily

Keys to control the ‚driver of cancer’s aggressiveness‘

A dangerous protein named SNAI2 helps cancers metastasize and shields cancer from both the immune system and chemotherapy. Worse, SNAI2 is in a family of proteins that are notoriously hard to fight with drugs. But now researchers have found a way to use the cell’s recycling system to control SNAI2, providing a new possibility for treatments.

Quelle: Sciencedaily

Engineered bacteria churn out cancer biomarkers

Pity the glycan. A lab has created these very tools by commandeering simple, single-celled microorganisms – namely E. coli bacteria – and engineering them to explore the complex process of glycosylation and the functional role that protein-linked glycans play in health and disease.

Quelle: Sciencedaily

Improving the efficacy of cellular therapies

A new study deepens the understanding of the development of T cell, an important component of the immune system.

Quelle: Sciencedaily

Why the dose matters: Study shows levels and anti-tumor effectiveness of a common drug vary widely

When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients. But determining the correct dosage of the drug to help treat cancer isn’t that simple, new research suggests.

Quelle: Sciencedaily

Discoveries made in how immune system detects hidden intruders

Research has led to better understanding on how components of the body’s immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments.

Quelle: Sciencedaily

Building bridges: PARP enzymes bring broken DNA together

Researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.

Quelle: Sciencedaily

The Wnt pathway gets even more complicated

A new role for Casein Kinase-1 on RNF43 is identified.

Quelle: Sciencedaily

Human white blood cells use molecular paddles to swim

Human white blood cells, known as leukocytes, swim using a newly described mechanism called molecular paddling, researchers report. This microswimming mechanism could explain how both immune cells and cancer cells migrate in various fluid-filled niches in the body, for good or for harm.

Quelle: Sciencedaily

Researchers use soy to improve bone cancer treatment

Researchers showed that the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation.

Quelle: Sciencedaily

Combining two precision medicines can treat drug-resistant cancers

Launching a dual-pronged attack on tumours using a combination of two innovative precision medicines could treat patients with multiple common cancers, a new clinical trial shows.

Quelle: Sciencedaily

Gene that drives ovarian cancer identified

Scientists have pinpointed which specific genes drive – or delay – high-grade serious ovarian carcinoma.

Quelle: Sciencedaily

New immunotherapy to beat cancer

Scientists have succeeded in neutralizing a molecule that blocks the immune system against cancer. The researchers discovered that this new immunotherapy increases the action of another well-known but not always effective immunotherapy, and that it makes tumor regression possible.

Quelle: Sciencedaily

DNA-based nanotechnology stimulates potent antitumor immune responses

Combining their expertise in protein engineering and synthetic DNA technology, scientists successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

Quelle: Sciencedaily

Epigenetic changes precede onset of diabetes

Epigenetic changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes. These changes are responsible for the altered methylation activity of specific genes which differs from that in healthy individuals. In humans, 105 such changes have been discovered in blood cells.

Quelle: Sciencedaily

Addicted to the sun? Research shows it’s in your genes

Sun-seeking behavior is linked to genes involved in addiction, behavioral and personality traits and brain function, according to a study of more than 260,000 people.

Quelle: Sciencedaily

Researchers solve decades old mitochondrial mystery that could lead to new disease treatments

Researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer.

Quelle: Sciencedaily

Cancer: Dismantling the web of death

Cancer is one of the most frequent causes of death. Chemotherapy is often used as a treatment, but also brings side effects for healthy organs. Scientists are now trying to take a completely different approach: By means of targeted and localized disruption of the cancer cells‘ structure, its self-destruction mechanism can be activated. In laboratory experiments, they have already demonstrated initial successes.

Quelle: Sciencedaily

New nanosystem enhances treatment for melanoma in animal models

Researchers have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.

Quelle: Sciencedaily

Small study shows convalescent plasma is safe to use in pediatric patients with COVID-19

Early findings show that convalescent plasma appears to be a safe and possibly effective treatment for children with life-threatening cases of COVID-19.

Quelle: Sciencedaily

How mutations in DNA packaging machines cause cancer

Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. When assembled correctly, these complexes play a crucial role in the development of normal tissues, and when broken, they can lead to the development of cancer. These complexes are commonly disrupted by mutations in the genes that encode them – but how this leads to cancer is poorly understood.

Quelle: Sciencedaily

Targeted drug found effective in patients who have lung cancer with certain mutations

A targeted therapy called capmatinib can provide significant benefits to patients who have advanced lung cancer with specific gene mutations, according to recently published results from a phase two clinical trial.

Quelle: Sciencedaily

Improving European healthcare through cell-based interceptive medicine

Hundreds of innovators, research pioneers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare. Scientists now present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next decade, to track, understand and treat human cells throughout an individual’s lifetime.

Quelle: Sciencedaily

Genome sequencing accelerates cancer detection

Recent cancer studies have shown that genomic mutations leading to cancer can occur years, or even decades, before a patient is diagnosed. Researchers have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing esophageal cancer. The results could enable early detection and improve treatment of oesophageal cancer in future.

Quelle: Sciencedaily