Traditionally, neuroscience regards the brain as being made up of two basic tissue types. Until very recently, not much was known about the interface between the white and grey matter – the so-called superficial white matter. Little was known about this thin region linking the grey and white matter because methods were lacking to study it in living human brains. Yet, previous investigations had suggested the region to be implicated in devastating conditions such as Alzheimer’s disease and autism. Now a multidisciplinary team led by Nikolaus Weiskopf from the MPI CBS has succeeded in making the superficial white matter visible in the living human brain.