ABC transporters: A novel approach to the development of antibiotics, immunotherapy medications and anti-cancer drugs

Antibiotics as well as important drugs for the treatment of cancer and immune diseases are produced by microorganisms through multi-modular enzyme complexes called non-ribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs). A research team led by Vetmeduni Vienna recently revealed that ABC transporters play an essential, hitherto unknown role in the biosynthesis of NRPS products. The genetic and biochemical data presented in the journal mBio provide information about a new, significant aspect of the biosynthesis of secondary microbial metabolites that are important for human and veterinary medicine – with practical relevance for the development of novel drug therapies.

Quelle: IDW Informationsdienst Wissenschaft