Blocking cellular communication stops SARS-CoV-2 – Patent on signaling inhibitor for COVID-19 treatment

FRANKFURT. Many viruses use and manipulate the communication pathways of their host cells to boost their own replication. Now, for the first time, biochemists and virologists from Goethe University and University Hospital Frankfurt have drawn a complete picture of communication within a human cell infected with SARS-CoV-2. In cell culture experiments, the researchers succeeded in stopping virus replication with a series of cancer drugs tested in clinical practice. The drugs target the places where several of the cell’s communication pathways meet (Molecular Cell, DOI 10.1016/j.molcel.2020.08.006). The scientists in Frankfurt have now filed a patent for their method.

Quelle: IDW Informationsdienst Wissenschaft