Statins: Researchers uncover how cholesterol-lowering drugs cause muscle pain

Patients who take statins in order to lower their blood cholesterol levels often complain about muscle problems, typically muscle pain. But why this occurs is still largely unresolved. In a recent study, the pharmaceutical scientists Professor Alexandra K. Kiemer und Jessica Hoppstädter from Saarland University have identified a potential causal relationship. According to the results of their work, statins cause enhanced production of a protein called ‘GILZ’ that impairs muscle cell function.
The study has been published in The FASEB Journal under the title ‘The Glucocorticoid-Induced Leucine Zipper Mediates Statin-Induced Muscle Damage’, DOI: 10.1096/fj.201902557RRR

Quelle: IDW Informationsdienst Wissenschaft