Loss of microRNA leads to fibrosis

Fibrosis describes a pathological stiffening of organs or tissues that is caused by the increased synthesis of extracellular proteins. Fibrosis severely impairs organ function and may occur in several organs, like lung, kidney and heart. It develops with increasing age and is also found in patients with liver cancer. A research team led by Professor Alfred Nordheim, Interfaculty Institute of Cell Biology of the University Tübingen and Scientific Director of the Leibniz Institute on Aging (FLI) in Jena, Germany, identified microRNAs that are responsible for fibrosis development. This may suggest potential approaches for the treatment of liver cancer and fibrosis formation in old age.

Quelle: IDW Informationsdienst Wissenschaft