Eating too much fat and sugar makes you overweight and unhealthy – even young children know that. But why is that, and is there anything we can do about it? In a study published in the journal Cell, Prof. Jens Brüning’s research group at the Max Planck Institute for Metabolism Research in Cologne has shown how altering fat metabolism in the liver can make obese mice thinner, despite eating an unhealthy diet. The process also improves the glucose metabolism of the mice. This is achieved by switching off a protein, called ceramide synthase 6.
Intervention in fat metabolism improves fatty liver disease and glucose metabolism of obese mice