Fishing in the protein pond using histones as a bait. How do cells decide how to repair their DNA?

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in ‚Nature Cell Biology‘, to which scientists from Helmholtz Zentrum München made major contributions, elucidates the molecular basis by which a cell makes the choice between these repair mechanisms. The trick the scientists used: they developed a molecular bait to literally fish out the relevant proteins from the cell nucleus. According to the authors, this study opens up new possibilities for cancer therapies in the future.

Quelle: IDW Informationsdienst Wissenschaft