Access control for proteins

The trans-Golgi network (TGN) is the central hub for the transport of proteins within and out of cells. As protein transport is essential for cell biology, the cell closely regulates which proteins are packaged and transported in vesicles. However, the process by which non-signal-carrying proteins are packaged is still poorly understood. A study carried out by the Research Group led by Julia von Blume at the Max Planck Institute of Biochemistry in Martinsried in collaboration with Christopher Burd’s Research Group at Yale University has now shown that the sorting of proteins into vesicles and lipid synthesis at the TGN are molecularly coupled. The study was published in Developmental Cell. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)