Drug design: Clues for drugging the ‚undruggable‘

Scientists have shown how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins — zinc finger transcription factors — play a role in cancer and developmental diseases but are difficult drug targets. The new study suggests that thalidomide analogs can be rationally designed to target this challenging class of proteins. (Mehr in: Cancer News — ScienceDaily)