Cleavage Product of Alzheimer’s Key Protein APP Stimulates Nerve Cell

A cleavage product of the Alzheimer’s APP protein stimulates nerve cell communication and memory. The protein fragment, known as APPsα, has neuroprotective properties and acts as a signal molecule on other nerve cells. But how does it influence brain functions? An international research team led by Prof. Dr Ulrike Müller of Heidelberg University has gained new insights into the molecular mechanism underlying its physiological functions. The researchers discovered a receptor for APPsα, which paves the way for new treatment approaches for Alzheimer’s. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)