Preeclampsia triggered by an overdose of gene activity

Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery. A research team led by the Max Delbrück Center for Molecular Medicine (MDC) has published new findings in the journal Circulation, which reveal that preeclampsia is not in fact a single disease caused solely by genetic factors. Their tests on placenta samples have shown that epigenetically regulated genes play an important role. The Berlin research team also developed an in vitro model of the disorder which demonstrates the dysregulation of an important transcription factor. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)