Oestrogen regulates pathological changes of bones via bone lining cells

The female sex hormone oestrogen protects the structural stability of bones. To date, however, it had been unclear exactly which cells were involved in the hormone’s protective function in preventing changes in bone density. Researchers at Vetmeduni Vienna were able to show for the first time that oestrogen uses a certain cell type as a “mediator” for its beneficial effects on bone. When oestrogen binds to these so-called “bone lining cells”, which cover the bone surfaces, it regulates the expression of a protein called RANKL in these cells. Oestrogen deficiency leads to uncontrolled expression of RANKL, which can trigger pathological changes in the bones. Published in Scientific Reports. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)