A closer look at brain organoid development

Heidelberg, 10 March 2017 – How close to reality are brain organoids, and which molecular mechanisms underlie the remarkable self-organizing capacities of tissues? Researchers already have succeeded in growing so-called “cerebral organoids” in a dish – clusters of cells that self-organize into small brain-like structures. Juergen Knoblich and colleagues have now further characterized these organoids and publish their results today in The EMBO Journal. They demonstrate that, like in the human brain, so-called forebrain organizing centers orchestrate developmental processes in the organoid, and that organoids recapitulate the timing of neuronal differentiation events found in human brains. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)