Stability of exhausted T cells limits durability of cancer checkpoint drugs

Reinvigorating exhausted T cells in mice using a PD-L1 blockade caused very few T memory cells to develop. After the blockade, re-invigorated T cells became re-exhausted if antigen from the virus remained high, and failed to become memory T cells when the virus was cleared, report scientists. (Mehr in: Cancer News — ScienceDaily)