Why is the immune system unable to combat HIV? Key factor identified

An international research group with essential participation of the Paul-Ehrlich-Institut, has identified NLRX1, a cellular factor of the human cell that is indispensable to the replication of Human Immunodeficiency Virus (HIV-1). This factor plays a key role in attenuating the innate immune system towards HIV-1. Until now, the significance of NLRX1 for the replication of HIV-1 and the attenuation of the immune system was not known. The novel research finding will lead to new therapeutic approaches. The research results are reported in Cell Host Microbe in its oedition of 13.04.2016 (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)