Experimental evidence for a novel mechanism of transposition – Vector choice and gene transfer

Transposons are mobile DNA segments that can cause disease, for example cancer, when they move to new locations in the genome. However, transposons can also be harnessed as tools for gene therapy of genetic diseases. Scientists at the Paul-Ehrlich-Institut, that evaluates such advanced therapies, discovered a new mechanism of genome shuffling by transposons (Nature Communications, 02.03.2016). By analysis of insertion sites of transposons and other gene transfer vehicles, the scientists also obtained evidence that the Sleeping Beauty transposon were inserted less frequently in undesired genomic locations than the other vector systems (Molecular Therapy, 12.01.2016). (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)